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Use the list of recommended applications curated by Trend Micro to exclude from Anti-Malware real-time scans.

Recommended Exclusions is a list of important applications Trend Micro recommends excluding from real-time scans to avoid impacts to endpoint performance or interruptions to application processes. You can view information about each application, including which policies and computers have assigned the exclusion, by selecting the application and clicking Properties.
You can manually assign recommended exclusions or allow agents to automatically apply recommended exclusions in the Anti-Malware settings. To discover if applications installed on your endpoints are recommended exclusions, Trend Micro recommends for